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Tuesday, 16 June 2015

Are you a woman? You like taking Drugs? These drugs can reduce your fertility

Drugs regularly taken to alleviate back pain 'significantly' reduce a woman’s fertility, doctors have warned. Researchers found a group of drugs, known as non-steroidal anti-inflammatory drugs (NSAIDs), ‘significantly inhibit ovulation’.
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NSAIDs are among the most commonly used drugs worldwide, and are taken by more than 30 million people every day. Available without prescription, they are largely used for the treatment of pain, inflammation and fever - all common features of conditions involving joint and muscle pain. They include naproxen, diclofenac, ibuprofen and aspirin.
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'After just ten days of treatment we saw a significant decrease in progesterone, a hormone essential for ovulation, across all treatment groups, as well as functional cysts in one third of patients,' said study investigator, Professor Sami Salman, of the University of Baghdad, Iraq. 'These findings show that even short-term use of these popular, over-the-counter drugs could have a significant impact on a women's ability to have children. ‘This needs to be better communicated to patients with rheumatic diseases, who may take these drugs on a regular basis with little awareness of the impact.'
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WHAT ARE NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)?
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Non-steroidal anti-inflammatory drugs (NSAIDs) are a medication widely used to treat a range of conditions. NSAIDs are used to: *.relieve pain *.reduce inflammation (redness and swelling) *.bring down a high temperature (fever) They are used to treat headaches, painful periods, toothache, soft tissue injuries such as sprains and strains and the symptoms of infections, such as the common cold or the flu. They are also prescribed to treat most types of arthritis, including rheumatoid arthritis, other forms of inflammatory arthritis and osteoarthritis, back pain and neck pain. Source: NHS Choices
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As part of the study, Professor Salman and his team tested three of the most commonly prescribed NSAIDs: diclofenac, naproxen and etoricoxib. They recruited 39 women of childbearing age who suffer from back pain to take part in the study. The women received diclofenac (100mg once daily), naproxen (500mg twice daily) and etoricoxib (90mg once daily) or a placebo. The drugs were given 10 days after the beginning of their menstrual cycle - the first day of a woman’s period. Researchers tested whether the women had ovulated by analysing the level of the hormone progesterone, via a blood sample. They also measured the diameter of the dominant follicle, a fluid-filled cavity in the ovaries that contains one undeveloped egg, using ultra sonography – a form of ultrasound. Rupturing of the dominant follicle, and subsequent release of an oocyte - an unfertilised egg - is essential for ovulation to occur. Of the women receiving NSAIDs, only 6.3 per cent of those taking diclofenac ovulated, they found. And only 25 per cent of women taking naproxen and 27.3 per cent taking etoricoxib ovulated.
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source: Dailymail

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